Despicable Me - one or more of the girls has a learning disability. (I'm picturing Ethel with ADD/ADHD, for some reason, but feel free to do whatever speaks to you.) How would this affect her in a technogeek-supervillain family? What challenges does this present Grue with as the parent of a special-needs child? Would Doctor Neutrino try to rewire her brain? Drama!

Bonus points if her Thing makes her able to more easily connect with/understand the Minions.