I nominated The Loved Ones - it's not clear which of Brent's injuries will prove permanent, but it seems very likely that the muteness will, and probably some of the other stuff as well. (Saying more would spoil the movie, rather.)
As for the rest of the fandoms, here are the ones I recognized and haven't seen mentioned. I've removed character names on those instances when using them would spoil a non-classic story.
Bend it Like Beckham - Joe has an injured knee.
Bourne Identity - Jason Bourne has amnesia.
Carnivale - oh my. Samson is a dwarf and walks with a cane, Jonesy has a limp, Management is a triple amputee, Lodz is blind, Appolonia is catatonic, Sabina has ectrodactyly, and there's a set of conjoined twins called Alexandria and Caladonia. It could probably be argued that Gabriel is developmentally disabled.
Charlotte Brontë: Jane Eyre - Rochester has one hand amputated and partially loses his eyesight. And while Bertha isn't exactly a good example for mental illness, she's definitely mentally ill.
Chocolat - Armande is diabetic.
Cornelia Funke: Inkheart - Resa is mute during the first book and part of the second. (Also for part of the movie.)
Degrassi High: Maya uses a wheelchair, Caitlin has epilepsy, Joey has dysgraphia
Degrassi Next Generation - Craig is bipolar, Jimmy uses a wheelchair (there may be more, I haven't seen much of this show)
Diana Wynne Jones: Chrestomanci series - Word of God says Cat is on the autistic spectrum, though the books don't make this clear
Diana Wynne Jones: Enchanted Glass - Tarquin has one leg (though he's taught a way to magically compensate).
Dick Francis: Sid Halley series - Sid uses a prosthetic hand.
Dr. Quinn Medicine Woman - the Reverend is blinded during the course of the series.
Due South - Diefenbaker is presumably deaf. Although he's also a wolf. (Is this fandom even eligible?)
E.R. - Kerry Weaver walks with a crutch, Robert Romano is an amputee, Reese (Peter Benton's son) is deaf.
Farscape - John Chrichton has some mental issues that are a combination of external torture and the pressure of being in outer space. These manifest themselves in various ways, hallucinations being one.
Firefly (I really doubt this is eligible) - River has paranoid schizophrenia (at least that's her brother's diagnosis).
Forrest Gump - Forrest is developmentally disabled, Lieutenant Dan is a double leg amputee.
Four Weddings and a Funeral - David is deaf.
Frasier - Martin walks with a cane.
Friday Night Lights - Jason is quadroplegic (with some use of his arms and hands).
Fried Green Tomatoes - a character loses an arm during the course of the story.
Fucking Åmål / Show Me Love - Viktoria is paraplegic.
Fullmetal Alchemist - Ed uses a prosthetic arm and leg. Another character is temporarily blinded.
The Hunchback of Notre Dame - well, duh...
Jericho - Bonnie is deaf.
Joan of Arcadia - Kevin is paraplegic.
Joanne Greenberg: I never promised you a rose garden - Deborah (and the author) is diagnosed with schizophrenia (whether or not that's correct).
Johanna Spyri: Heidi - Clara uses a wheelchair for a while.
L.A. Confidential - One of the characters is shot towards the end of both book and film, with temporary or permanent disabilities as a result.
Leverage - Word of God says Parker has Asperger's.
The Little Mermaid - Ariel is temporarily rendered mute (though it's permanent in the book - or, well, she dies. So permanent until that.)
MacGyver - Pete becomes blind during the course of the series.
Maggie Stiefvater: Shiver - in addition to the werewolf thing, Sam has psychological issues that could probably best be described as PTSD.
Mark Z. Danielewski: House of Leaves - Zampanò is blind, Perafina has a mental illness, Billy Reston is paraplegic.
Memento - Leonard has anterograde amnesia.
Michael Ondaatje: The English Patient - The titular character has severe burns. Caravaggio has both thumbs cut off.
Miguel de Cervantes: Don Quixote - I'm not sure what the protagonist's mental issues would be called, but they're doubtlessly there.
Moonstruck - Ronny uses a prosthetic hand.
My Own Private Idaho - Mike has narcolepsy.
Mythology: Greek and Roman - Hephaestus walks with a limp.
Mythology: Norse - Tyr loses his hand in the jaws of the Fenris wolf.
The Oddyssey (TV show) - Jay spends much of the show in a coma, and has some issues waking up. Donna uses a crutch and leg brace.
Open Hearts (Elsker dig for evigt) - Joachim is paraplegic.
Penelope - Penelope's pig curse aside, Lemon is a dwarf and one-eyed.
Press Gang - though I very much doubt anyone will write him, Billy Homer is quadroplegic (or tetraplegic, as he calls it).
ReGenesis - Bob has Asperger's.
Road to Avonlea - Jasper has a stutter. Another character is blinded towards the end of the series, and it's uncertain whether or not he'll recover.
Rome - Caesar has epilepsy.
Saved! - Roland is paraplegic.
SeaQuest - Dagwood is developmentally disabled. J.J. Fredericks ("Freddy") has severe anxiety/PTSD, which is managed through a chip in her head. Anthony Piccolo is dyslexic.
Second Sight - Tanner has severe vision loss.
Steel Magnolias - Shelby has diabetes.
Stephen King: The Stand - Nick is deaf (deaf-mute, according to the book), Tom is developmentally disabled.
Suzanne Collins: The Hunger Games trilogy - one of the characters has hir leg amputated by the end of the first book.
Threshold - Ramsey is a dwarf.
Tin Man - Glitch has had half his brain removed through magical means.
United States of Tara - Tara has DID.
Up - Carl uses a cane.
William Golding: Lord of the Flies - Piggy has vision problems that become acute as his glasses are destroyed. Simon has seizures (epilepsy?)
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Date: 2010-10-22 08:56 pm (UTC)As for the rest of the fandoms, here are the ones I recognized and haven't seen mentioned. I've removed character names on those instances when using them would spoil a non-classic story.
Bend it Like Beckham - Joe has an injured knee.
Bourne Identity - Jason Bourne has amnesia.
Carnivale - oh my. Samson is a dwarf and walks with a cane, Jonesy has a limp, Management is a triple amputee, Lodz is blind, Appolonia is catatonic, Sabina has ectrodactyly, and there's a set of conjoined twins called Alexandria and Caladonia. It could probably be argued that Gabriel is developmentally disabled.
Charlotte Brontë: Jane Eyre - Rochester has one hand amputated and partially loses his eyesight. And while Bertha isn't exactly a good example for mental illness, she's definitely mentally ill.
Chocolat - Armande is diabetic.
Cornelia Funke: Inkheart - Resa is mute during the first book and part of the second. (Also for part of the movie.)
Degrassi High: Maya uses a wheelchair, Caitlin has epilepsy, Joey has dysgraphia
Degrassi Next Generation - Craig is bipolar, Jimmy uses a wheelchair (there may be more, I haven't seen much of this show)
Diana Wynne Jones: Chrestomanci series - Word of God says Cat is on the autistic spectrum, though the books don't make this clear
Diana Wynne Jones: Enchanted Glass - Tarquin has one leg (though he's taught a way to magically compensate).
Dick Francis: Sid Halley series - Sid uses a prosthetic hand.
Dr. Quinn Medicine Woman - the Reverend is blinded during the course of the series.
Due South - Diefenbaker is presumably deaf. Although he's also a wolf. (Is this fandom even eligible?)
E.R. - Kerry Weaver walks with a crutch, Robert Romano is an amputee, Reese (Peter Benton's son) is deaf.
Farscape - John Chrichton has some mental issues that are a combination of external torture and the pressure of being in outer space. These manifest themselves in various ways, hallucinations being one.
Firefly (I really doubt this is eligible) - River has paranoid schizophrenia (at least that's her brother's diagnosis).
Forrest Gump - Forrest is developmentally disabled, Lieutenant Dan is a double leg amputee.
Four Weddings and a Funeral - David is deaf.
Frasier - Martin walks with a cane.
Friday Night Lights - Jason is quadroplegic (with some use of his arms and hands).
Fried Green Tomatoes - a character loses an arm during the course of the story.
Fucking Åmål / Show Me Love - Viktoria is paraplegic.
Fullmetal Alchemist - Ed uses a prosthetic arm and leg. Another character is temporarily blinded.
The Hunchback of Notre Dame - well, duh...
Jericho - Bonnie is deaf.
Joan of Arcadia - Kevin is paraplegic.
Joanne Greenberg: I never promised you a rose garden - Deborah (and the author) is diagnosed with schizophrenia (whether or not that's correct).
Johanna Spyri: Heidi - Clara uses a wheelchair for a while.
L.A. Confidential - One of the characters is shot towards the end of both book and film, with temporary or permanent disabilities as a result.
Leverage - Word of God says Parker has Asperger's.
The Little Mermaid - Ariel is temporarily rendered mute (though it's permanent in the book - or, well, she dies. So permanent until that.)
MacGyver - Pete becomes blind during the course of the series.
Maggie Stiefvater: Shiver - in addition to the werewolf thing, Sam has psychological issues that could probably best be described as PTSD.
Mark Z. Danielewski: House of Leaves - Zampanò is blind, Perafina has a mental illness, Billy Reston is paraplegic.
Memento - Leonard has anterograde amnesia.
Michael Ondaatje: The English Patient - The titular character has severe burns. Caravaggio has both thumbs cut off.
Miguel de Cervantes: Don Quixote - I'm not sure what the protagonist's mental issues would be called, but they're doubtlessly there.
Moonstruck - Ronny uses a prosthetic hand.
My Own Private Idaho - Mike has narcolepsy.
Mythology: Greek and Roman - Hephaestus walks with a limp.
Mythology: Norse - Tyr loses his hand in the jaws of the Fenris wolf.
The Oddyssey (TV show) - Jay spends much of the show in a coma, and has some issues waking up. Donna uses a crutch and leg brace.
Open Hearts (Elsker dig for evigt) - Joachim is paraplegic.
Penelope - Penelope's pig curse aside, Lemon is a dwarf and one-eyed.
Press Gang - though I very much doubt anyone will write him, Billy Homer is quadroplegic (or tetraplegic, as he calls it).
ReGenesis - Bob has Asperger's.
Road to Avonlea - Jasper has a stutter. Another character is blinded towards the end of the series, and it's uncertain whether or not he'll recover.
Rome - Caesar has epilepsy.
Saved! - Roland is paraplegic.
SeaQuest - Dagwood is developmentally disabled. J.J. Fredericks ("Freddy") has severe anxiety/PTSD, which is managed through a chip in her head. Anthony Piccolo is dyslexic.
Second Sight - Tanner has severe vision loss.
Steel Magnolias - Shelby has diabetes.
Stephen King: The Stand - Nick is deaf (deaf-mute, according to the book), Tom is developmentally disabled.
Suzanne Collins: The Hunger Games trilogy - one of the characters has hir leg amputated by the end of the first book.
Threshold - Ramsey is a dwarf.
Tin Man - Glitch has had half his brain removed through magical means.
United States of Tara - Tara has DID.
Up - Carl uses a cane.
William Golding: Lord of the Flies - Piggy has vision problems that become acute as his glasses are destroyed. Simon has seizures (epilepsy?)
The Young Riders - Ike is mute.
Zorro - Felipe is mute.